The role of pig in somatic cell cloning and transgenesis
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
A stimulus for development of the studies on pig somatic cell cloning, especially in recent years, was above all the possibility of its practical application for production of transgenic piglets using in vitro transfected nuclear donor cells and multiplication of genetically-engineered sows and boars generated so far, on the grounds of important implications for biomedicine, pharmacy and agriculture. However, effective pig somatic cell nuclear transfer, avoiding the sexual reproduction pathway, creates a possibility of providing numerous monoge- netic and monosexual offspring derived not only from genetically-transformed individuals, but also from adult (postpubertal) animals of high genetic merit. Generation of cloned transgenic pigs for biomedical purposes to obtain recombinant xenogeneic proteins or organs suitable in xenotransplantology, or to create cell (gene) therapy foundations for a number of serious monogenic diseases that induce heritable (congenital) developmental anomalies, is perceived as a service to humanity.
Biotechnologia, vol.72, 1 (2006)-.
0860-7796 ; oai:rcin.org.pl:87768 ; IChB B-68
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
Oct 2, 2020
Dec 13, 2019
488
https://rcin.org.pl/ichb/publication/114732
Edition name | Date |
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Znaczenie świni dla klonowania somatycznego i transgenezy | Oct 2, 2020 |
Skrzyszowska, Maria Samiec, Marcin
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Samiec, Marcin
Samiec, Marcin
Samiec, Marcin