Jura, Jacek ; Słomski, Ryszard ; Smorąg, Zdzisław ; Gajda, Barbara ; Wieczorek, Jarosław ; Lipiński, Daniel ; Kalak, Robert ; Juzwa, Wojciech ; Zeyland, Joanna
Production of pigs used in xenotransplantation
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
There are four main trends in the use of transgenic animals. One of the most interesting is the use of transgenic animals as the donors of tissue or organs suitable for transplantation in human - xenotransplantation. This field of research has been undergoing intensive and increasing study during the past few years, and some encouraging progress is being made. A pig has been identified as the most suitable donor animal. The aim of the presented experiment was to produce transgenic pigs which tissues and organs could be used for the xenotransplantation needs. To target the goal, a competitive gene construct coding the same substrate as the endogenous enzyme of organ donor was introduced. In effect, transgenic boar was produced with confirmed integration of human a/,2 fucosyltransferase gene. Also, FI generation of transgenic pigs was generated to preserve ongoing needs of preliminary research of xenotransplantation project.
Biotechnologia, vol.72, 1 (2006)-.
0860-7796 ; oai:rcin.org.pl:87839 ; IChB B-68
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
2 paź 2020
13 gru 2019
1205
https://rcin.org.pl/ichb/publication/114788
Nazwa wydania | Data |
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Uzyskiwanie świń wykorzystywanych w ksenotransplantacji | 2 paź 2020 |
Lipiński, Daniel Szalata, Marlena Kalak, Robert Pławski, Andrzej Nuc, Katarzyna Kala, Marta Juzwa, Wojciech Słomska, Karolina Gronek, Piotr Jura, Jacek Jura, Jolanta Smorąg, Zdzisław Pieńkowski, Marek Słomski, Ryszard
Lipiński, Daniel Juzwa, Wojciech Zeyland, Joanna Słomski, Ryszard
Jura, Jacek Smorąg, Zdzisław Gajda, Barbara Kareta, Wiesław Kopchick, John J. Kelder, Bruce Prieto, Pedro A.
Jura, Jacek Smorąg, Zdzisław Kątska, Lucyna Skrzyszowska, Maria Gajda, Barbara Ryńska, Bożenna
Smorąg, Zdzisław Jura, Jacek Kopchick, John J. Gajda, Barbara Skrzyszowska, Maria Różycki, Marian Pasieka, Jarosław
Smorąg, Zdzisław
Gajda, Barbara Smorąg, Zdzisław