Modified catalytic ribonucleic acids
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Over the last decade, modified oligoribonucleotides have emerged as avaluable tool in catalytic RNA studies. The range of incorporated nucleotide analogues includes modifications in the base, sugar or phosphate moieties. Thecomparisons of the properties of the modified RNA enzymes with unmodifiedmodels allow one to draw the conclusions concerning the importance of specific functional groups within the catalytic RNA. In this review, we discuss theselected examples of modified oligonucleotides applications to investigatesome aspects of mechanisms and structure/function relationships of smallribozymes (hammerhead and hairpin). The importance of modifications for theimprovement of ribozyme catalytic activity and resistance to nucleases are alsopresented.
Biotechnologia, vol.61, 2 (2003)-.
0860-7796 ; oai:rcin.org.pl:135648 ; IChB B-57
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Oct 2, 2020
Aug 19, 2020
489
https://rcin.org.pl/ichb/publication/170583
Edition name | Date |
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Modyfikowane, katalityczne kwasy rybonukleinowe | Oct 2, 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Nowak, Jacek K.