Inny tytuł:

Strategy of directed RNA degradation and selected examples of its usein antiviral therapy

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstrakt:

Over the last decade, antisense oligodeoxynucleotides and ribozymes haveemerged as valuable biochemical tools and promising therapeutic reagents inmedicine. This review describes the basic principles of their use in the strategyof directed RNA degradation. The rules for the rational choice of targeted RNAsequences, the properties of available RNA cleaving tools, as well as the majorproblems that limit the effectiveness of this new technology, are discussed. Selected examples of the successful use of antisense oligonucleotides and ribozymesas antiviral agents are presented.

Czasopismo/Seria/cykl:

Biotechnologia, vol.56, 1 (2002)-.

Tom:

56

Zeszyt:

1

Strona pocz.:

57

Strona końc.:

70

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

0860-7796 ; oai:rcin.org.pl:138381 ; IChB B-52

Źródło:

Library of Institute of Bioorganic Chemistry PAS

Język:

pol

Język streszczenia:

eng

Zakres czasowy:

1988-2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open