Inny tytuł:

Mechanical damage of animal cells in bioreactors

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstrakt:

Fluid-mechanical damages of shear sensitive animal cells due to forces generated by mediaagitation and aeration are reviewed. In anchorage-dependent cultures grown in a stirred bioreactor the cell damage is caused by small turbulent eddies of size of the microcarrier beads andby collision between microcarriers and against the impeller and the stationary parts of bioreactor.In the freely suspended cells grown in stirred or air-lift reactors the cell damage is due mainlyto air bubble breakup. The mechanical damages can be limited by an increase of kinematicviscosity of fluid and reduction of the local energy dissipation rate. Biological aspects of shearstress are also discussed.

Czasopismo/Seria/cykl:

Biotechnologia, vol.22, 3 (1993)-.

Tom:

22

Zeszyt:

3

Strona pocz.:

166

Strona końc.:

183

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

0860-7796 ; oai:rcin.org.pl:154171 ; IChB B-18

Źródło:

Library of Institute of Bioorganic Chemistry PAS

Język:

pol

Język streszczenia:

eng

Zakres czasowy:

1988-2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open