Chemically modified siRNA duplexes
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
RNA interference (RNAi) is a powerful biological process for a sequence-specific silencing of a gene expression in diverse eukaryotic cells. Discovery of this phenomena had tremendous significance for functional genomics and development of novel gene-specific therapies. The future success of RNAi technology relies on identifying appropriate chemical modifications to improve stability, potency and in vivo cellular delivery of the effector moieties, siRNAs. The presented review attempts to describe some of the biological challenges associated with using synthetic siRNAs to effect RNAi and summarizes the role of the chemical tools in the application of RNAi technology.
Biotechnologia, vol.90, 3 (2010)-.
oai:rcin.org.pl:71502 ; IChB B-85
Biblioteka Instytutu Chemii Bioorganicznej PAN
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
2 paź 2020
23 maj 2019
1064
https://rcin.org.pl/ichb/publication/93557
Nazwa wydania | Data |
---|---|
Modyfikowane chemicznie dupleksy siRNA | 2 paź 2020 |
Borkowska, Bożenna
Sierant, Małgorzata Okruszek, Andrzej
Sierant, Małgorzata Nawrot, Barbara
Sierant, Małgorzata Okruszek, Andrzej
Sławińska, Anna Siwek, Maria
Tyczewska, Agata Bąkowska- Żywicka, Kamila
Pieczyński, Marcin Bielewicz, Dawid Dolata, Jakub Szweykowska-Kulińska, Zofia