File of histopathological evaluation of nervous system diseases (1964) - nr 167/64

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Title: File of histopathological evaluation of nervous system diseases (1964) - nr 167/64

Abstract:

Histological diagnosis: Astrocytoma partim astroblastoma malignum.Autopsy examination of 81-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and van Gieson method.Both sampled foci were conglomerates of neoplastic tissue, hemorrhage, and necrosis. In the center of the fairly well-demarcated foci, a partially preserved, partially disintegrating, neoplastic tissue was visible among the disintegrated blood cells and macrophages. This tissue was polymorphic, but with respect to different foci, in individual islands it retained a fairly similar structure. Most common were foci of chromatin cells, with large astrocyte-like nuclei and elongated protoplasm. These cells formed characteristic perivascular arrangements. There were 2-3 mitotic figures in the field of view. In other clusters, the cells were spindle-shaped, with abundant round hyperchromatic cells. In fields cut transversely, these arrangements assumed the character of small round cells. Fields with a mixed cell population appeared less frequently. Often, entire sections of the tumor utricle were obliterated by structure following necrosis. The vessels within and surrounding the tumor were vitreously altered. Astrocytic infiltrates, consisting of regular mast cells, hyperplastic astrocytes and proliferating astrocytes, were disseminated in and outside the fields of necrosis; in addition, clusters of astrocyte-like macrophages with a morphology consistent with Opalski's cells were found