The role of pig in somatic cell cloning and transgenesis
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
A stimulus for development of the studies on pig somatic cell cloning, especially in recent years, was above all the possibility of its practical application for production of transgenic piglets using in vitro transfected nuclear donor cells and multiplication of genetically-engineered sows and boars generated so far, on the grounds of important implications for biomedicine, pharmacy and agriculture. However, effective pig somatic cell nuclear transfer, avoiding the sexual reproduction pathway, creates a possibility of providing numerous monoge- netic and monosexual offspring derived not only from genetically-transformed individuals, but also from adult (postpubertal) animals of high genetic merit. Generation of cloned transgenic pigs for biomedical purposes to obtain recombinant xenogeneic proteins or organs suitable in xenotransplantology, or to create cell (gene) therapy foundations for a number of serious monogenic diseases that induce heritable (congenital) developmental anomalies, is perceived as a service to humanity.
Biotechnologia, vol.72, 1 (2006)-.
0860-7796 ; oai:rcin.org.pl:87768 ; IChB B-68
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Oct 2, 2020
Dec 13, 2019
488
https://rcin.org.pl/ichb/publication/114732
Edition name | Date |
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Znaczenie świni dla klonowania somatycznego i transgenezy | Oct 2, 2020 |
Skrzyszowska, Maria Samiec, Marcin
Skrzyszowska, Maria Samiec, Marcin
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Samiec, Marcin
Samiec, Marcin
Samiec, Marcin