Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

Wiśniewska, K. dr

Place of publishing:

Warsaw

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Autopsy examination of 85-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and van Gieson. In the left parietal lobe, there was a degenerative focus of malacia, mainly involving the cortex, in stage of advanced glial-mesodermal organization. The focus area was characterized by complete obliteration of the layered structure of the cortex. Nerve cells were replaced by progressively or regressively altered glia. The vasculature was stimulated, and there were often numerous macrophages laden with blood-derived pigment. The first layer of cortex was generally unchanged, containing numerous gemistiocytes and amyloid bodies. In some areas, the cortex was spongy in nature. Vacuolations and cellular disorders were found in the vicinity of the focus. Throughout the nervous system, the vessels were vitreously and fibrously altered, and single macrophages with hemosiderin were seen around some of them. Features of edema were observed.

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:206368

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open