Department of Experimental and Clinical Neuropathology MMRI
Clinical, anatomical and histological diagnosis
Histological diagnosis: Encephalomalacia inveterata. Autopsy examination of 64-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and Van Gieson's method.A specimen taken from the malcia focus revealed necrosis destroying the white matter and cortex, with a partially preserved fine layer. The focus was in an advanced stage of organization. In the central part, remnants of disintegrating tissue, macrophages and a dense capillary network, rich in collagen fibers, were visible. Besides, numerous smaller foci forming post infarct cavities, perivascular sinuses, and old glial scars were observed in the white matter. Nerve cells in the cortex showed features of fatty degeneration and chronic disease. Lymphocytic cells, sometimes macrophages, were present in the vicinity of the focus of malacia, next to highly atherosclerotic vessels..
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Mossakowski Medical Research Institute PAS
Library of the Mossakowski Medical Research Institute PAS
Feb 1, 2022
Jul 9, 2021
41
https://rcin.org.pl/imdik/publication/232834
Edition name | Date |
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opis nr 92/65 | Feb 1, 2022 |