Twórca instytucjonalny:

Department of Experimental and Clinical Neuropathology MMRI

Współtwórca:

I. Zelman, doc.

Miejsce wydania:

Warsaw

Opis:

Clinical, anatomical and histological diagnosis

Abstrakt:

Histological diagnosis: Phenylketonuria. Autopsy examination of 1-year-old child was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, Cresyl-violet and Heidenhain method.Morphological examination revealed that the brain was small in relation to the child's weight, gyrus were small, and the ventricular system was dilated. Microscopically, a generalized reduction of white matter in relation to the grey structures was very evident, and within it there was marked demyelination, more severe in the cerebral hemispheres, less in the cerebellum. It was accompanied by tissue damage with foci of spongiform necrosis and cell-fibrous gliosis. Grey structures and especially the cerebral cortex also showed significant damage.Histological diagnosis: Phenylketonuria

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:197159

Język:

pol

Język streszczenia:

eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open