Seasonal Variations in Melatonin Secretory Rhythms in High-, Middle-, and Low-Latitude Regions

Morita, Takeshi; Błażejczyk, Krzysztof

doi:0033-2143 (print)

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Title: Seasonal Variations in Melatonin Secretory Rhythms in High-, Middle-, and Low-Latitude Regions

Abstract:

This study aims to measure the daily melatonin secretory rhythms of people living in high-, mid-, and low-latitude regions characterised by different day lengths and global solar-radiation conditions. In Poland, a high-latitude region, the amount of melatonin secretion is greater, with secretion occurring earlier (exemplifying phase advance). On the other hand, in Vietnam, a low-latitude region, the level is lower and occurs later (phase delay). Japan, a mid-latitude region, shows behaviour intermediate between these two. Melatonin secretory rhythm in Vietnam is closely related to Day length and Global Solar Radiation, though no such relationship is observed in Poland or Japan, making it necessary for other factors to be considered. The results of this study have important implications considering the impacts of light pollution and lighting-related conditions of modern life.
; This study aims to measure the daily melatonin secretory rhythms of people living in high-, mid-, and low-latitude regions characterised by different day lengths and global solar-radiation conditions. In Poland, a high-latitude region, the amount of melatonin secretion is greater, with secretion occurring earlier (exemplifying phase advance). On the other hand, in Vietnam, a low-latitude region, the level is lower and occurs later (phase delay). Japan, a mid-latitude region, shows behaviour intermediate between these two. Melatonin secretory rhythm in Vietnam is closely related to Day length and Global Solar Radiation, though no such relationship is observed in Poland or Japan, making it necessary for other factors to be considered. The results of this study have important implications considering the impacts of light pollution and lighting-related conditions of modern life.

References:

Błażejczyk, B., Morita, T., Ueno-Towatari, T., Błażejczyk, A., & Wieczorek, J. (2014). Seasonal and regional differences in lighting conditions and their influence on melatonin secretion. Quaestiones Geographicae, 33(3), 17‑25. https://doi.org/10.2478/quageo-2014-0026
Burgess, H.J., & Fogg, L.F. (2008). Individual differences in the amount and timing of salivary melatonin secretion. PLoS One, 3, e3055. https://doi.org/10.1371/journal.pone.0003055
Cain, S.W., Dennison, C.F., Zeitzer, J.M., Guzik, A.M., Khalsa, S.B., Snthi, N., Scoen, M.W., Czeisler, C.A., & Duffy, J.F. (2010). Sex differences in phase angle of entrainment and melatonin amplitude in humans. Journal of Biological Rhythms, 25(4), 288‑296. https://doi.org/10.1177/0748730410374943
Cutler, N.L., Lewy, A.L., Sack, R.L. & Ahmed, S. (1995). Stability in timing and amplitude of melatonin production across four seasons in humans. Sleep Res, 24, 517.
Czarnecka, K., Błażejczyk, K., & Morita, T. (2021). Characteristics of light pollution - A case study of Warsaw (Poland) and Fukuoka (Japan). Environmental Pollution, 291, 1‑8. https://doi.org/10.1016/j.envpol.2021.118113
Duffy, J.F., & Wright, K.P.Jr. (2005). Entrainment of the human circadian system by light. Journal of Biological Rhythms, 20(4), 326‑338. https://doi.org/10.1177/0748730405277983
Fideleff, H.L., Boquete, H., Fideleff, G., Albornoz, L., Perez Lloret, S., Suarez, M. Esquifino, A.I., Honfi, M., & Cardinali, D.P. (2006). Gender-re; ated differences in urinary 6-sulfatoxymelatonin levels in obese pubertal individuals. Journal of Pineal Research, 40(3), 214‑218. https://doi.org/10.1111/j.1600-079X.2005.00301.x
Hébert, M., Martin, S.K., Lee, C., & Eastman, C.I. (2002). The effects of prior light history on the suppression of melatonin by light in humans. Journal of Pineal Research. 33(4), 198‑203. https://doi.org/10.1034/j.1600-079x.2002.01885.x
Higuchi, S., Motohashi, Y., Ishibashi, K., & Maeda, T. (2007). Less exposure to daily ambient light in winter increases sensitivity of melatonin to light suppression. Chronobiology International, 24(1), https://doi.org/10.1080/07420520601139805
Higuchi, S., Motohashi, Y., Ishibashi, K., & Maeda, T. (2007). Influence of eye colors of Caucasians and Asians on suppression of melatonin secretion by light. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 292(6), R2352-R2356. https://doi.org/10.1152/ajpregu.00355.2006
Honma, K., Honma, S., Kohsaka, M., & Fukuda, N. (1992). Seasonal variation in the human circadian rhythm: dissociation between sleep and temperature rhythm. American Journal of Physiology, 262(5), R885-R891. https://doi.org/10.1152/ajpregu.1992.262.R885
Illnerova, H., Zvolsky, P., & Vanecek, J. (1985). The circadian rhythm in plasma melatonin concentration of the urbanized man. Brain Res, 328(1), 186‑189. https://doi.org/10.1016/0006-8993(85)91342-3
Kennaway, D.J., & Royles, P. (1986). Circadian rhythms of 6-sulphatoxy melatonin, cortisol and electrolyte excretion at the summer and winter solstices in normal men and women. Acta Endocrinol (Copenh), 113(3), 450‑456. https://doi.org/10.1530/acta.0.1130450
Kivela, A., Kauppila, A., Ylostalo, P., Vakkuri, O., & Leppaluoto, J. (1988). Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women. Acta physiologica Scandinavica, 132(3), 321‑327. https://doi.org/10.1111/j.1748-1716.1988.tb08335.x
Lewy, A.L. (2007). Melatonin and human chronobiology. Cold Spring Harbor Symposia on Quantitative Biology, 72, 623‑636. https://doi.org/10.1101/sqb.2007.72.055
Morera, A.L., & Abreu, P. (2006). Seasonality of psychopathology and circannual melatonin rhythm. Journal of Pineal Research, 41(3), 279‑283. https://doi.org/10.1111/j.1600-079x.2006.00365.x
Nathan, P.J., Wyndham, E.L., Burrows, G.D., & Norman, T.R. (2000). The effect of gender on the melatonin suppression by light: a dose response relationship. Journal of Neural Transmission, 107(3), 271‑279. https://doi.org/10.1007/s007020050022
Owen, J., & Arendt, J. (1992). Melatonin suppression in human subjects by bright and dim light in Antarctica: time and season-dependent effects. Neuroscience Letters, 137(2), 181‑184. https://doi.org/10.1016/0304-3940(92)90399-r
Reiter, R.J. (1993). The melatonin rhythm: both a clock and a calendar. Experientia, 49(8), 654‑664. https://doi.org/10.1007/BF01923947
Riemann, D., Klein, T., Rodenbeck, A., Feige, B., Horny, A., Hummel, R., Weske, G., Al-Shajlawi, A., & Voderholzer, U. (2002). Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiatry Research, 113, 17‑27. https://doi.org/10.1016/s0165-1781(02)00249-4
Roenneberg, T., & Foster, R.G. (1997). Twilight times: light and the circadian system. Photochemistry and Photobiology, 66, 549‑561. https://doi.org/10.1111/j.1751-1097.1997.tb03188.x
Roenneberg, T., Kumar, C.J., & Merrow, M. (2007). The human circadian clock entrains to sun time. Current Biology, 17, R44-R45. https://doi.org/10.1016/j.cub.2006.12.011
Roenneberg, T., Kantermann, T., Juda, M., Vetter, C., & Allebrandt, K.V. (2013). Light and the human circadian clock. Handbook of Experimental Pharmacology, 217, 311‑331. https://doi.org/10.1007/978-3-642-25950-0_13
Sack, R.L., Lewy, A.J., Erb, D.L., Vollmer, W.M., & Singer, C.M. (1986). Human melatonin production decreases with age. Journal of Pineal Research, 3, 379‑388. https://doi.org/10.1111/j.1600-079x.1986.tb00760.x
Stokkan, K.A., & Reiter, R.J. (1994). Melatonin rhythms in Arctic urban residents. Journal of Pineal Research, 16, 33‑36. https://doi.org/10.1111/j.1600-079x.1994.tb00079.x
Stothard, E.R., McHill, A.W., Depner, C.M., Birks, B.R., Moehlman, T.M., Ritchie, H.K., Guzzetti, J.R., Chinoy, E.D., LeBourgeois, M.K., Axelsson, J., &Wright, K.P Jr. (2017). Circadian Entrainment to the natural light-dark cycle across seasons and the weekend. Current Biology, 27, 508‑513. http://doi.org/10.1016/j.cub.2016.12.041
Touitou, Y., Fevre, M., Bogdan, A., Reinberg, A., De Prins, J., Beck, H., & Touitou, C. (1984). Patterns of plasma melatonin with ageing and mental condition: stability of nyctohemeral rhythms and differences in seasonal variations. Acta Endocrinol (Copenh), 106, 145‑151. https://doi.org/10.1530/acta.0.1060145
Ueno-Towatari, T., Norimatsu, K., Błażejczyk, K., Tokura, H., & Morita, T. (2007). Seasonal variation of melatonin secretion in young females under natural and artificial light conditions in Fukuoka, Japan. Journal of Physiological Anthropology, 26, 209‑215. https://doi.org/10.2114/jpa2.26.209
Vondrasova, D., Hajek, I., & Illnerova, H. (1997). Exposure to long summer days affects the human melatonin and cortisol rhythms. Brain Res, 759, 166‑170. https://doi.org/10.1016/s0006-8993(97)00358-2
Wehr, T.A. (1991). The duration of human melatonin secretion and sleep respond to changes in daylength (photoperiod). The Journal of Clinical Endocrinology & Metabolism, 73, 1276‑1280. https://doi.org/10.1210/jcem-73-6-1276
Wehr, T.A., Moul, D.E., Barbato, G., Giesen, H.A., Seidel, J.A., Baker, C., & Bender, C. (1993). Conservation of photoperiod-responsive mechanisms in humans. American Journal of Physiology, 265, R846-R857. https://doi.org/10.1152/ajpregu.1993.265.4.R846
Yoneyama, S., Hashimoto, S., & Honma, K. (1999). Seasonal changes of human circadian rhythms in Antarctica. American Journal of Physiology, 277(4), R1091-R1097. https://doi.org/10.1152/ajpregu.1999.277.4.R1091
Zerbini, G., Winnebeck, E.C., & Merrow, M. (2021). Weekly, seasonal, and chronotype-dependent variation of dim-light melatonin onset. Journal of Pineal Research, 70, e12723. https://doi.org/10.1111/jpi.12723