Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

M.Dąmbska, dr hab.

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Encephalopathia cum hydrocephalus et ulegyria post encephalitidem. Diastomatomyelia. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained by Hematoxylin-eosin, Cresyl violet and Van Gieson's stain as well as Heidenhain’s azan.Pathological changes resulting from two separate disease processes were observed. 1/ Within the cerebral hemispheres extensive damage resulting from past inflammatory process. Wide hydrocephalic ventricles with a layer of subcortical glia. Cortex with extensive scarring. Nerve cells focally completely absent, in some areas single or in larger clusters. All nerve cells shrunken. White matter similarly shows different types and degrees of damage. In less damaged areas, myelin was clearly visible. The basal ganglia were preserved with similar damage to the rest of the hemispheres – surprisingly, the Luis nucleus is well preserved. The hypertrophic fibrotic meninges with discrete meningeal reaction. Cerebellum and brainstem without significant changes except for minor cellular damage and disruption of myelination of pyramidal tracts. 2/ At the medulla level a split cord malformation was observed. In the cervical segment, spinal cord was duplicated, each in the meningeal sac, progressing to a single dysplastic and shrunken medulla in the thoracic segment. The spinal cord in the cervical segment was well-developed. Reduced number and apparent cell damage in the anterior horn with completely preserved Clark's pole cells were seen.

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:193513

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open