Filters
RCIN and OZwRCIN projects

Search for: [Abstract = "Praziquantel \(PZQ\) is a drug which is used by choice to schistosomiasis treatment. Currently, it is used in malaria treatment. PZQ undergoes extensive metabolism in human body, mainly in liver, by two cytochrome P\-450 isoenzymes 2B1 and 3A. As a result of these biotransformations, numerous mono\- and dihydroxylated derivates in B, C and D rings are formed. Only one metabolite has been identified and described, it is 4\-hydroxypraziquantel \(4\-OH\-PZQ\). So far, the metabolites out of PZQ biotransformation were obtained under the influence of Ciinnighamelle echinulata and Beauveria bassiana. There were the derivatives in position C7 and in D\-ring \(position is unknown\)."]

Number of results: 1

Items per page:

Godawska, Anna Pękala, Elżbieta Kieć-Kononowicz, Katarzyna

2005
Text

This page uses 'cookies'. More information