Search for: [Abstract = "Praziquantel \(PZQ\) is a drug which is used by choice to schistosomiasis treatment. Currently, it is used in malaria treatment. PZQ undergoes extensive metabolism in human body, mainly in liver, by two cytochrome P\-450 isoenzymes 2B1 and 3A. As a result of these biotransformations, numerous mono\- and dihydroxylated derivates in B, C and D rings are formed. Only one metabolite has been identified and described, it is 4\-hydroxypraziquantel \(4\-OH\-PZQ\). So far, the metabolites out of PZQ biotransformation were obtained under the influence of Ciinnighamelle echinulata and Beauveria bassiana. There were the derivatives in position C7 and in D\-ring \(position is unknown\)."]

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