Department of Experimental and Clinical Neuropathology MMRI
Clinical, anatomical and histological diagnosis
Histological diagnosis: Atrophia cerebri. Arteriosclerosis cerebri.Autopsy examination of 71-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and van Gieson method and frozen section s stain with Bielschowsky method.In the cortex, cellular desolations were observed, obliterating in parts its layered structure. Nerve cells were often steatotic, some showed features of chronic disease. The changes were most pronounced in the third and fifth layer and perivascularly. Large atherosclerotic lesions were present. The vessels, especially in the basal ganglia and white matter, presented changes typical of vitrification and fibrosis, fibrous changes were observed in the cortex. Lymphocyte-like cells, macrophages with hemosiderin and pseudocalcium salts were seen near some vessels. Besides, there were features of congestion and edema. In the meninges, single macrophages were present in some areas. No senile plaques were found in the cortex or basal ganglia.
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Mossakowski Medical Research Institute PAS
Library of the Mossakowski Medical Research Institute PAS
Feb 1, 2022
Sep 14, 2021
40
https://rcin.org.pl/imdik/publication/246317
Edition name | Date |
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opis nr 184/63 | Feb 1, 2022 |