The following effects of 5-min postdecaptivc ischemia on the metabolic propertiesof guinea pig brain mitochondria have been observed: 1) remarkable inhibition of mitochondria respiratory activity in state 3; 2) oxidative phosphorylation uncoupling togethcr with a decrease in ADP/O ratio and RC index; 3) increase in the Mg++-stimulated ATPase with a simultaneous decrease of ATPase activity dependent on DNP. A twofold increase in the free fatty acids content ofthese mitochondria has been noticed, and the effect of exogenous olcate on the metabolic pro-perties of brain mitochondria has been shown to be similar to that on liver mitochondria. Oleate inhibits respiratory activity of brain mitochondria, uncouplcs oxidative phosphorylation, stimulates ATPase activity dependent on Mg + + and at the same time inhibits ATPase induced by DNP. It also inhibits ATP-Pi exchange and produces swelling of brain mitochondria. The obtained re-sults suggested that free fatty acids liberated in the brain during ischemia may —through their inhibitory activity on energy metabolism of mitochondria — become one of the factors of the development of irreversible brain damages in ischemia.
Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.
Oct 2, 2020
Aug 27, 2019
|Effects of ischemia and exogenous fatty acids on the energy metabolism in brain mitochondria||Oct 2, 2020|
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