Contributor:

Michalski, Andrzej ; Łukasiewicz, Hanna ; Olszewski, Waldemar ; Nielubowicz, Jan

Publisher:

PZWL

Place of publishing:

Warszawa

Type of object:

Czasopismo/Artykuł

Abstract:

Experimental investigations, consisting in intravenous administration of various amounts of the pancreatic juice were carried out in dogs. Pancreatic juice was taken sterilely from the dog-donor. Experiments were done in 5 groups. In the 1st group gradually increasing amounts of the pancreatic juice were administered to 7 dogs, with purpose to determine eventual lethal dose. In the 2nd group, 11 dogs received pancreatic juice in amount more than 55 ml/kg of body weight. In the 3rd group, 3 dogs were administered inactivated pancreatic juice, also in amount more than 55 ml/kg of body weight. In the 4th group 3 dogs were administered intravenously 0,9% of natrium chloride solution with merthiolate added. In the 5th group 3 dogs received transfusion of 100 mg of trypsine, dissolved in borate buffer solution (acc. to Michaelis). Foilwing results were obtained: pancreatic juice administered intravenously in amount of 55 ml/kg of body weight, during some 20—25 minutes, caused death of the experimental animals. All remaining animals survived.Clinical symptoms observed after pancreatic juice administration seem to be causally joined with the action of the group of pancreatic enzymes. Attemps to determine which a these enzymes arc responsible for tht described effect, failed

Relation:

Polski Przegląd Chirurgiczny 1965, 37, nr 4

Volume:

37

Issue:

4

Start page:

490

End page:

496

Detailed Resource Type:

Article

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:80977

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Copyright holder:

Olszewski, Waldemar

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open