Apoptosis in oogenesis and preimplantation embryo development of mammals
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
In this paper, the authors made an attempt to summarize the present knowledge on apoptosis in mammalian oocytes and embryos. On the contrary to necrosis, apoptosis is a programmed death of damaged or mutated cells. Several studies showed that it takes place during oogenesis (oocyte growth and maturation), as well as at some stages of preimplantation embryo development (morula, blastocyst). Although apoptosis is observed in vivo, the frequency of this phenomenon increases in vitro. There is a number of methods detecting apoptotic cells, however, none of them gives a clear evaluation of the studied process. A complex analysis with the use of several methods is therefore advised. Because in ovary the majority of oocytes undergo atresia (over 99%), the scientists concentrate on developing new methods aiming at improvement of females’ reproductive performance. The process of apoptosis seems to be a crucial limiting factor.
Biotechnologia, vol.68, 1 (2005)-.
0860-7796 ; oai:rcin.org.pl:112050 ; IChB B-64
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
2 paź 2020
4 lut 2020
871
https://rcin.org.pl/publication/140314
Nazwa wydania | Data |
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Apoptoza w oogenezie i wczesnym rozwoju zarodkowym ssaków | 2 paź 2020 |
Lechniak, Dorota Warzych, Ewelina Pers-Kamczyc, Emilia
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Lechniak, Dorota
Nowak, Jacek K.