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This publication is protected by copyright. Check the terms of use in the publication description.
This publication is protected by copyright. Check the terms of use in the publication description.

Title: Adenosine effects on renal functionin the rat: role of sodium intake and cytochrome P450

Contributor:

Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

Publisher:

Karger

Place of publishing:

Basel

Type of object:

Book/Chapter

Abstract:

Adenosine (ADO) causes vasodilation in most tissues. In the kidney it can induce vasoconstriction or vasodilation, depending on the prevailing stimulation of A1 or A2 receptors (A1R, A2R). ADO-induced alterations of renal excretion may be secondary to haemodynamic changes, or reflect a direct influence on tubular transport. This whole-kidney study explored renal excretory responses to ADO receptor stimulation as related to renal haemodynamics sodium intake and cytochrome P450 (CYP-450) activity.METHODS: The effects of ADO or an A2aR agonist (DPMA) on urine flow (V), sodium excretion (UNaV) and total solute excretion were examined in anaesthetized Wistar rats on a low-sodium or high-sodium (HS) diet. Total renal blood flow (RBF; renal artery probe), and outer- and inner-medullary blood flows (OM-BF, IM-BF; laser-Doppler fluxes) were also determined.RESULTS: Consistent opposed effects of ADO and DPMA were only observed with the HS diet. ADO increased V (150%) and UNaV (100%); there were also significant increases in RBF, OM-BF and IM-BF. These changes were prevented by 1-aminobenzotriazol, a CYP-450 inhibitor. In HS rats, DPMA significantly decreased arterial blood pressure and renal excretion.CONCLUSIONS: Post-ADO diuresis/natriuresis was in part secondary to renal hyperperfusion; the response was probably mediated by CYP-450-dependent active agents. Selective A2aR stimulation induced systemic vasodilation, major hypotension, and a secondary decrease in renal excretion

Relation:

Nephron Physiology

Volume:

123

Issue:

1-2

Start page:

1

End page:

5

Detailed Resource Type:

Article

Format:

text/xml

Resource Identifier:

oai:rcin.org.pl:57120

Language:

eng

Language of abstract:

eng

Rights:

Rights Reserved - Restricted Access

Terms of use:

Copyright-protected material. Access only on terminals at the Mossakowski Medical Research Center of the Polish Academy of Sciences, may be used within the limits of statutory user freedoms.

Digitizing institution:

Mossakowski Medical Research Center PAS

Original in:

Library of the Mossakowski Medical Research Center PAS

Projects co-financed by:

Programme Innovative Economy, 2010-2014, Priority Axis 2. R&D infrastructure

Access:

Closed

Object collections:

Last modified:

Nov 30, 2021

In our library since:

Dec 22, 2015

Number of object content hits:

78

All available object's versions:

https://rcin.org.pl/publication/77962

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