Contributor:

Kompanowska-Jezierska, Elżbieta (Promotor)

Publisher:

Medical Research Center Polish Academy of Sciences

Place of publishing:

Warszawa

Description:

Bibliogr. zawiera 233 pozycji ; 179 s. : il., wykr. ; 30 cm

Degree name:

doctor

Level of degree:

2

Degree discipline :

biologia medyczna

Degree grantor:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Abstract:

The aim of study was to deterine physiological parametres with biochemical parametres (angiotensin II level in tissues and plasma, Ang II), that let us take a look on chymase and other chymastation sensitive enzymes role in the devlopment of hypertension in various hypertension miodels in rat. The in vivo role these enzymes in various hypertension models in tissues and plasma has been determined. We used genetic model of hypertension in two different stages (SHR7 in the developing stage and SHR 16 in the established stage hypertension), sodium-dependent (UNX HS) and renal artery stenosis-dependent -Goldblatt model, 2K1C). The in vivo effects of simultaneous blockade of systemic and tissue rennin-angiotensin-aldosterone system ( RAAS) on blood pressure and renal function in SHR has been established.The last part of this study was the veryfication of peptides from rapesseeds and its potential value in antyhypertension treatment on cardiovascular system and renal excertion in genetic model of hypertension (SHR). As our in vivo study indicated, that chymostatin sensitive enzymes play a substantial role in plasma and tissue regulation of Ang II content, and combined inhobition of two different pathways of Ang II synthesis ( systemic and tissue RAAS) could be much more effucient in the treatment of hypertension.

Detailed Resource Type:

PhD Dissertations

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:58993

Source:

IMDiK PAN, call no. ZS 360 ; click here to follow the link

Language:

pol

Rights:

Prawa zastrzeżone - dostęp nieograniczony

Terms of use:

Zasób chroniony prawem autorskim. Korzystanie dozwolone w zakresie określonym przez przepisy o dozwolonym użytku.

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Program Operacyjny Innowacyjna Gospodarka, lata 2010-2014, Priorytet 2. Infrastruktura strefy B + R ; Unia Europejska. Europejski Fundusz Rozwoju Regionalnego

Access:

Open