Systemic hemodynamic abnormalities, functional heart disturbances and itsstructural lesions, alteration in acid-base equilibrium and early development ofbrain edema, accompanying prolonged global cerebral ischemia are considered tobe important factors limiting restoration of brain function during recirculationperiod. It was decided to counteract these factors pharmacologically, by applyingthe following drugs: 1. Afronad (Roche) — to prevent hypertonic reaction in theearly period of ischemia, 2. Levonar (Polfa) — to keep arterial pressure during therecirculation period on the level close to control, 3. Tris (Fresenuis, A.G) — to counteractdisturbances of acid-base equilibrium, and 4. Mannitol (Polfa) — to protectagainst development of early brain edema. Experiments were carried out on 9adult rabbits, in which, under pentobarbital anesthesia (35 mg/kg b.w.), totalcerebral ischemia was produced by ligation of brain supplying arteries at their outcomepoint from the aortal arch. In all animals the pharmacological treatmentprevented successfully systemic hemodynamic disturbances, functional heart abnormalitiesand alterations of acid-base equilibrium. It extended the survival timeof 6 out of 9 examined animals to 24 h. The restoration time of the bioelectricactivity of the brain in all animals did not differ essentially from that in untreatedones. Normalization of ECoG pattern with respect to both its frequency and amplitudewas higher than in untreated animals. In all the animals secondary deteriorationof the cerebral bioelectric activity appeared arround 8th h of the recoveryperiod, worsening further during the later period of survival. Brain pathomorphologyrevealed cellular ischemic changes spread over all cerebral structures,being most intensive in the brain stem and cerebellum. In only one animal, featuresof brain edema were found. However, hemorrhagie foci, resulting from pharmacologicaltreatment were a common finding.
Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.
Sep 19, 2019
Feb 26, 2019
Kapuściński, Andrzej Mossakowski, Mirosław Jan (1929 - 2001)
Mossakowski, Mirosław Jan (1929 - 2001) Zelman, Irmina B (1927-2010) Kroh, Halina
Kapuściński, Andrzej Mossakowski, Mirosław Jan (1929 - 2001) Albrecht, Jan Januszewski, Sławomir Stowarzyszenie Neuropatologów Polskich
Mossakowski, Mirosław Jan (1929 - 2001) Instytut Medycyny Doświadczalnej i Klinicznej PAN Zakład Neuropatologii
Mossakowski, Mirosław Jan (1929 - 2001) Gajkowska, Barbara
Mossakowski, Mirosław Jan (1929 - 2001) Gadamski, Roman (1933 - 2015) Stowarzyszenie Neuropatologów Polskich
Mossakowski, Mirosław Jan (1929 - 2001) Kwiatkowska-Patzer, Barbara
Obtułowicz, Patrycja Domańska-Janik, Krystyna (Promotor) Sarnowska, Anna (Promotor pomocniczy)