Object

Title: Endothelial nitric oxide synthase in vascular endothelium of rat hippocampus after ischemia evidence and significance

Subtitle:

Wpływ niedokrwienia mózgowego na syntetazę tlenku azotowego w komórkach śródbłonka

Publisher:

Severus Publishing House

Place of publishing:

Warsaw

Abstract:

Electron microscopy immunocytochemical study was performed to clarify ultrastructural localization and role of endothelial nitric oxide synthase (EC-NOS) in the endothelial cells (EC) of rat hippocampal vessels after transient cerebral ischemia. EC-NOS immunoreactivity was found in the endothelial cells in association with plasma membrane, sub-plasmalemmal vesicles, basal membrane and in cytosol (cytoplasm free of subcellular organelles). A sharp transient increase in immunoreactivity of NOS was observed at 10 min up to 1 hour after ischemia. The results of the present study indicate that NO, as a potent vasodilator, may play a protective role in ischemic brain damage.

Relation:

Folia Neuropathologica

Volume:

35

Issue:

3

Start page:

171

End page:

180

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:71905 ; oai:rcin.org.pl:71905

Language:

eng

Language of abstract:

eng ; pol

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Center PAS

Original in:

Library of the Mossakowski Medical Research Center PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

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