Formanowicz, Piotr ; Urbaniak, Radosław ; Handschuh, Luiza ; Formanowicz, Dorota ; Figlerowicz, Marek
Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
DNA microarrays are widely used in many areas of biological research. They are an efficient tool for gene expression analysis due to a high level of parallelism, what means that they allow for simultaneous measuring of the transcriptional activity of all genes present in the studied genome. The quality of the results obtained using microarrays depends among other factors on the proper design of probes. Two general features which should characterize each probe are sensitivity and specificity. Since designing a set of probes having both of these properties is usually a complex task, many algorithms supporting this process have been developed and implemented. However, the designing method should be carefully chosen such that the results will match the requirements following from the nature of the biological problem to be solved. In this paper the criteria used for DNA microarray design are described and some computer based approaches are presented.
Biotechnologia, vol.83, 4 (2008)-.
0860-7796 ; IChB-78 ; oai:rcin.org.pl:73247
Library of Institute of Bioorganic Chemistry PAS
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Oct 2, 2020
Jun 18, 2019
805
https://rcin.org.pl/publication/95922
Edition name | Date |
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Mikromacierze DNA - zasady projektowania sond | Oct 2, 2020 |
Handschuh, Luiza Lewandowski, Krzysztof Kaźmierczak, Maciej Komarnicki, Mieczysław Figlerowicz, Marek
Żmieńko, Agnieszka Handschuh, Luiza Góralski, Michał Figlerowicz, Marek
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan