Publisher:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Place of publishing:

Wrocław ; Warszawa ; Kraków

Type of object:

Journal/Article

Abstract:

The protective effect of Nimotop (Bayer) — a calcium channel blocker, beingan equivalent of nimodipine, on the development of selective damage of CAi neuronsof Ammon’s horn resulting from short-term ischemia of forebrain in Mongoliangerbils was evaluated. The experimental animals, subjected to 7.5 min bilateralligation of common carotid arteries were given the drug in a dosis of 1 mg/kgbody weight in the form of intraperitoneal injection at various periods in relationto cerebral ischemia. In group 1 — Nimotop was administered twice — 60 mjnbefore ischemia and 5 h after arterial release. In group 2 a double dosis of thedrug was given 15 min prior to carotid occlusion and in 3rd hour of the recirculation.In group 3 the scheme applied in group 2 was supplemented with a thirddosis of Nimotop given 24 h following cerebral ischemia. The latter was the timeof a single drug dosis application in group 4. The control animals were subjectedto cerebral ischemia with no medication.

Relation:

Neuropatologia Polska

Volume:

25

Issue:

4

Start page:

439

End page:

450

Detailed Resource Type:

Article

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:68727

Language:

pol

Language of abstract:

eng ; rus

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open