Object

Title: Zróżnicowanie progresji inokulowanego czerniaka u linii myszy o wysokiej i niskiej wrażliwości na stres

Creator:

Ragan, Agnieszka Renata

Date issued/created:

2015

Resource type:

Text

Contributor:

Sacharczuk, Mariusz (Promotor)

Publisher:

Instytut Genetyki i Hodowli Zwierząt , ; Medical Research Center Polish Academy of Sciences

Place of publishing:

Jastrzębiec ; Warszawa

Description:

113 s.: il., fotogr. ; 30 cm

Degree name:

doctor

Level of degree:

2

Degree discipline :

biologia medyczna

Abstract:

The study was focused of finding the relationship between endogenous differences in the magnitude of stress reaction and melanoma susceptibility . We utilized two mouse lines of divergent levels of stress induced analgesia : HA (high analgesia) and LA (low analgesia). During the study we inoculated both HA and LA mice with B16F0 melanoma cells. We measured melanoma progression , variations in pain levels and the magintude of depression-like behaviour in animals. The result showed , that HA line is prone both to stress induced sickness -behaviour and melanoma inoculation , whie LA line , showing mild response to stress is generally melanoma resistant. In HA line melanoma tumors were developed both in stress and control conditions , but environmental and social stress we factors contributing to faster and enhanced progression of lensions. It is noteworthy , that majority of LA specimen were melanoma resistant and in the mice in which the tumor started developing it regressed spontaneusly. To undrstend the mechanisms responsible for divergent melanioma progression in HA and LA mice we used , among others cytogenetic , molecular , histological and behavioral assays , but no clear evidence indicated the basis of the diferences. We persume that sublte variations in opiod system reactivity , as well as shifts in level of eosinophlils may play a patrial role.

Detailed Resource Type:

PhD Dissertations

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:58996

Source:

IMDiK PAN, call no. ZS 359 ; click here to follow the link

Language:

pol

Rights:

Prawa zastrzeżone - dostęp nieograniczony

Digitizing institution:

Mossakowski Medical Research Center PAS

Original in:

Library of the Mossakowski Medical Research Center PAS

Object collections:

Last modified:

Jun 23, 2016

In our library since:

Jun 23, 2016

Number of object content hits:

1 536

All available object's versions:

https://rcin.org.pl/publication/78692

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