Expression of milk protein genes is regulated by hormones, growth factors and extracellularmatrix. Prolactin, the major lactogenic hormone, promotes all stages of casein gene expression.Besides prolactin, also growth hormone may directly induce expression of milk protein genes.Computer analysis, mutation experiments and DNA-protein binding experiments enabled identification of mammary-specific transcription factors and cis-regulatoiy sequences in milk proteingene promoters. Also, transgene technology enables recognition of regulatory sequences in milkprotein genes. Moreover, transgenic animals carrying structural genes of human proteins fusedto mammary specific promoters are considered as living “bioreactors” designated to producehuman proteins for pharmaceutical use.
Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.
Nov 13, 2020
Nov 13, 2020
|Structure, expression and engineering of miik protein genes||Nov 13, 2020|
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Maj, Andrzej Zwierzchowski, Lech
Nowak, Jacek K.