Subtitle:

Thiol-activated hemolysins as virulence markers of bacteria

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Abstract:

The article contains information regarding the similarities and differencesbetween proteins of the thiol-activated cytolysins family (TACY). Members ofthis group of haemolysins are produced by several species of Gram-positive bacteria {Listeria spp., Streptococcus spp., Bacillus spp., Clostridium spp.,) and also byGram-negative Klebsiella spp. Their cytolytic activity is sensitive to oxygen andcan be restored by adding reducing compounds. TACY bind to cholesterol-containing membranes to form pores. Preincubation of the toxin with smallamounts of cholesterol inhibits hemolytic activity as well as cytolysis ofeucaryotic cells. Members ofthe group show 40-70% similarity in amino acid sequence, and contain an almost invariant Trp-rich undecapeptide sequence(ECTGLAWEWWR). The TACY are important virulence factors. Recently increased use has been made of molecular methods (PCR, hybridization) in the detection and identification of the TACY producing bacteria.

Relation:

Biotechnologia, vol.54, 3 (2001)-.

Volume:

54

Issue:

3

Start page:

152

End page:

168

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:138884 ; IChB B-50

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

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