Twórca instytucjonalny:

Department of Experimental and Clinical Neuropathology MMRI

Współtwórca:

J. Korthals, lek.

Miejsce wydania:

Warsaw

Opis:

Clinical, anatomical and histological diagnosis

Abstrakt:

Histological diagnosis: Malacia cerebri inveterata et cerebelli rubra recens. Arteriosclerosis cerebri. Autopsy examination of 65-year-old pa tient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and Van Gieson's method.In the right frontal lobe there was a triangular focus of malacia destroying the white matter and spreading to the cortex, with partial preservation of the fine layer. In the central part of the focus a cavity was visible, containing remnants of disintegrating tissue, vessels and macrophages. The focus was in the phase of glial-mesodermal organization. The tissue structure, especially the white matter was very loosened. In the vicinity of the foci in the cortex, atrophy and cellular disorders of ischemic type were visible. Some cells showed features of lipofuscin accumulation. The vessels were hypertrophied, with swollen endothelium and single macrophages around the vessels were seen. There were small symptomatic vascular infiltrates of lymphocytic cells. Fresh hemorrhagic necrosis was observed in several areas of the cerebellum. Disintegrating tissue with obliterated structure with islets of macrophages was seen in the focus. In the vicinity, atrophy of the granular layer and Purkinje cells was evident. The vessels in both examined specimens presented large atherosclerotic lesions.

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:197147

Język:

pol

Język streszczenia:

eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open